Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with Multiple Sclerosis susceptibility

GZM Ma; J Stankovich; TJ Kilpatrick; MD Binder; J Field; M Bahlo; DR Booth; S Broadley; MA Brown; BL Browning; SR Browning; H Butzkueven; WM Carroll; P Danoy; SJ Foote; L Griffiths; RN Heard; AG Kermode; J Lechner-Scott; P Moscato; VM Perreau; RJ Scott; M Slee; GJ Stewart; BV Taylor; J Wiley

Journal article

Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with Multiple Sclerosis susceptibility

GZM Ma, J Stankovich, TJ Kilpatrick, MD Binder, J Field, M Bahlo, DR Booth, S Broadley, MA Brown, BL Browning, SR Browning, H Butzkueven, WM Carroll, P Danoy, SJ Foote, L Griffiths, RN Heard, AG Kermode, J Lechner-Scott, P Moscato Show all

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011

DOI: 10.1371/journal.pone.0016964

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Abstract

Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) have been implicated as important players during demyelination in both animal models of MS and in the human disease. We therefore conducted an association study to identify single nucleotide polymorphisms (SNPs) within genes encoding the TAM receptors and their ligands associated with MS. Analysis of genotype data from a genome-wide association study which consisted of 1618 MS cases and 3413 healthy controls conducted by the Australia and New Zealand Multiple Sclerosis Genetics Cons..

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University of Melbourne Researchers

Trevor Kilpatrick Author

Michele Binder Author

Judith Field Author

Melanie Bahlo Author

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Grants

Awarded by Perpetual Trustees Australia Ltd

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by a grant from Perpetual Trustees Australia Ltd (Grant number 387) and the Australian Research Council (Linkage Project Grant Number LP0776744). G.Z.M.M is supported by an Australian Postgraduate Award. J.F. is supported by a Multiple Sclerosis Research Australia Fellowship. The Florey Neuroscience Institutes is supported by funding provided from the Operational Infrastructure Scheme of the Department of Innovation, Industry and Regional Development, Victoria, Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. I have read the journal's policy and have the following conflicts: This work was funded by Perpetual Trustees Australia Ltd. This does not alter the authors' adherence to all the PloS ONE policies on sharing data and materials.